概述

  • 产品名称Anti-Frizzled 7抗体
    参阅全部 Frizzled 7 一抗
  • 描述
    山羊多克隆抗体to Frizzled 7
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chicken, Cow, Dog, Xenopus laevis, Chimpanzee, Rhesus monkey
  • 免疫原

    Synthetic peptide:

    C-RFYHRLSHSSKGET

    , corresponding to C terminal amino acids 559-572 of Human Frizzled 7 (NP_003498.1).

  • 阳性对照
    • HEK293 and HepG2 cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab77379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Antibody detection limit dilution 1/64000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 64 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
    • 组织特异性High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
    • 序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • 结构域Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.
      The FZ domain is involved in binding with Wnt ligands.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Frizzled 7, seven transmembrane spanning receptor antibody
      • frizzled class receptor 7 antibody
      • Frizzled drosophila homolog of 7 antibody
      • Frizzled family receptor 7 antibody
      • Frizzled homolog 7 antibody
      • Frizzled-7 antibody
      • Frizzled7 antibody
      • Fz 7 antibody
      • Fz-7 antibody
      • Fz7 antibody
      • FZD 7 antibody
      • FZD7 antibody
      • FZD7_HUMAN antibody
      • FzE 3 antibody
      • FzE3 antibody
      • hFz 7 antibody
      • hFz7 antibody
      • Homolog of Drosophila Frizzled 7 antibody
      • OTTHUMP00000163742 antibody
      see all

    Anti-Frizzled 7 antibody 图像

    Anti-Frizzled 7 antibody (ab77379)参考文献

    ab77379 has not yet been referenced specifically in any publications.

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