Anti-Frizzled 7抗体(ab14472)

概述

性能

应用

Our Abpromise guarantee covers the use of ab14472 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/250 - 1/500. Predicted molecular weight: 64 kDa.

靶标

  • 功能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
  • 组织特异性High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
  • 序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.
  • 结构域Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.
    The FZ domain is involved in binding with Wnt ligands.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Frizzled 7, seven transmembrane spanning receptor antibody
    • frizzled class receptor 7 antibody
    • Frizzled drosophila homolog of 7 antibody
    • Frizzled family receptor 7 antibody
    • Frizzled homolog 7 antibody
    • Frizzled-7 antibody
    • Frizzled7 antibody
    • Fz 7 antibody
    • Fz-7 antibody
    • Fz7 antibody
    • FZD 7 antibody
    • FZD7 antibody
    • FZD7_HUMAN antibody
    • FzE 3 antibody
    • FzE3 antibody
    • hFz 7 antibody
    • hFz7 antibody
    • Homolog of Drosophila Frizzled 7 antibody
    • OTTHUMP00000163742 antibody
    see all

Anti-Frizzled 7 antibody (ab14472)参考文献

ab14472 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. To our knowledge, this antibody has yet to be tested in this application. All tested applications are specified on Abcam product datasheets. If you decide to go ahead and purchase this product, please let us know how you ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"