Anti-Frizzled 6抗体(ab105192)

概述

  • 产品名称Anti-Frizzled 6抗体
    参阅全部 Frizzled 6 一抗
  • 描述
    兔多克隆抗体to Frizzled 6
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region between amino acids 656-706 of Human Frizzled 6 (NP_003497.2)

  • 阳性对照
    • HeLa whole cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: Tris citrate/phosphate buffer, pH 7-8
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab105192 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use a concentration of 2 - 5 µg/ml.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear.
    • 组织特异性Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.
    • 疾病相关Nail disorder, non-syndromic congenital, 10
      Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy.
    • 序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • 结构域Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
      The FZ domain is involved in binding with Wnt ligands.
    • 翻译后修饰Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
    • 细胞定位Membrane. Cell membrane. Cell surface. Apical cell membrane. Cytoplasmic vesicle membrane. Colocalizes with FZD3 at the apical face of cells (By similarity).
    • Information by UniProt
    • 数据库链接
    • 别名
      • Frizzled 6 seven transmembrane spanning receptor antibody
      • Frizzled drosophila homolog of 6 antibody
      • Frizzled family receptor 6 antibody
      • Frizzled homolog 6 (Drosophila) antibody
      • Frizzled homolog 6 antibody
      • Frizzled-6 antibody
      • Frizzled6 antibody
      • Fz 6 antibody
      • Fz-6 antibody
      • Fz6 antibody
      • FZD 6 antibody
      • Fzd6 antibody
      • FZD6_HUMAN antibody
      • Hfz 6 antibody
      • hFz6 antibody
      • NDNC10 antibody
      see all

    Anti-Frizzled 6 antibody 图像

    • ab105192 at 0.4 µg/ml staining Frizzled 6 in HeLa whole cell lysate immunoprecipitated using ab105192 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence. Exposure time: 3 seconds

    Anti-Frizzled 6 antibody (ab105192)参考文献

    ab105192 has not yet been referenced specifically in any publications.

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