Anti-Frizzled 2抗体(ab94913)


  • 产品名称Anti-Frizzled 2抗体
    参阅全部 Frizzled 2 一抗
  • 描述
    兔多克隆抗体to Frizzled 2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Cow, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 2-51 RPRSALPRLL LPLLLLPAAG PAQFHGEKGI SIPDHGFCQP ISIPLCTDIA of Human Frizzled 2 (NP_001457).

  • 阳性对照
    • Human fetal spleen lysate



Our Abpromise guarantee covers the use of ab94913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 63 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • 功能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
  • 组织特异性Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.
  • 序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.
  • 结构域Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.
    The FZ domain is involved in binding with Wnt ligands.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Frizzled homolog 2 antibody
    • Frizzled-2 antibody
    • Frizzled2 antibody
    • Fz 2 antibody
    • Fz-2 antibody
    • Fz2 antibody
    • FZD 2 antibody
    • FZD2 antibody
    • FZD2_HUMAN antibody
    • FzE 2 antibody
    • FzE2 antibody
    • hFz 2 antibody
    • hFz2 antibody
    • Mfz10 antibody
    see all

Anti-Frizzled 2 antibody 图像

  • Anti-Frizzled 2 antibody (ab94913) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal spleen lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 63 kDa

Anti-Frizzled 2 antibody (ab94913)参考文献

ab94913 has not yet been referenced specifically in any publications.

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Thank you for your message. For my information on the expression levels of Frizzled 2 I was referring to various sources some of which revealed ambiguous results, such as the ArrayExpress gene expression database (

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Thank you for taking the time to complete our questionnaire and contact us. I am sorry to hear you have had difficulty obtaining satisfactory results from this antibody. The details you have kindly provided will enable us to investigate this case fo...

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