概述

  • 产品名称Anti-FREM2抗体
    参阅全部 FREM2 一抗
  • 描述
    兔多克隆抗体to FREM2
  • 经测试应用适用于: WB, ELISA, IHC-P, ICCmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to 19 internal sequence amino acids of Human FREM2.

  • 阳性对照
    • Human Breast and Human Kidney tissues.

性能

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应用

Our Abpromise guarantee covers the use of ab117612 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 351 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.
ICC Use at an assay dependent concentration.

靶标

  • 功能Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.
  • 疾病相关Defects in FREM2 are a cause of Fraser syndrome (FRASS) [MIM:219000]. Fraser syndrome is a multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects.
  • 序列相似性Belongs to the FRAS1 family.
    Contains 5 Calx-beta domains.
    Contains 12 CSPG (NG2) repeats.
  • 结构域The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp781I048 antibody
    • ECM3 homolog antibody
    • FRAS1-related extracellular matrix protein 2 antibody
    • FREM 2 antibody
    • Frem2 antibody
    • FREM2_HUMAN antibody
    • KIAA1074 antibody
    see all

Anti-FREM2 antibody 图像

  • ab117612, at 5 µg/ml, staining FREM2 in Formalin-fixed, Paraffin-embedded Human breast tissue by Immunohistochemistry.
  • ab117612, at 5 µg/ml, staining FREM2 in Formalin-fixed, Paraffin-embedded Human Kidney tissue by Immunohistochemistry.

Anti-FREM2 antibody (ab117612)参考文献

ab117612 has not yet been referenced specifically in any publications.

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