概述

  • 产品名称
    Anti-FRAT1抗体[EPR3900]
    参阅全部 FRAT1 一抗
  • 描述
    兔单克隆抗体[EPR3900] to FRAT1
  • 经测试应用
    适用于: WB, IP, ICC, Flow Cytmore details
    不适用于: IHC-P
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) (internal sequence)

  • 阳性对照
    • HeLa and MCF7 cell lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

性能

应用

Our Abpromise guarantee covers the use of ab108405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 29 kDa.
IP 1/10 - 1/100.
ICC 1/100 - 1/250.
Flow Cyt 1/500 - 1/1000.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

  • 应用说明
    Is unsuitable for IHC-P.
  • 靶标

    • 相关性
      The protein encoded by the FRAT1 gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and also positively regulates the Wnt signaling pathway. It may play a role in tumor progression and in lymphomagenesis.
    • 细胞定位
      Cytoplasmic
    • 数据库链接
    • 别名
      • FRAT 1 antibody
      • frequently rearranged in advanced T cell lymphomas antibody
      • Frequently rearranged in advanced T-cell lymphomas antibody
      • GSK 3 binding protein FRAT1 antibody
      • proto oncogene FRAT1 antibody
      see all

    图片

    • All lanes : Anti-FRAT1 antibody [EPR3900] (ab108405) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : MCF7 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 29 kDa

    文献

    This product has been referenced in:
    • Werner TV  et al. MiR-34a-3p alters proliferation and apoptosis of meningioma cells in vitro and is directly targeting SMAD4, FRAT1 and BCL2. Aging (Albany NY) 9:932-954 (2017). WB . Read more (PubMed: 28340489) »
    • Zhu K  et al. FRAT1 expression regulates proliferation in colon cancer cells. Oncol Lett 12:4761-4766 (2016). Read more (PubMed: 28101222) »

    See all 5 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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