概述

  • 产品名称Anti-FOXP1抗体
    参阅全部 FOXP1 一抗
  • 描述
    兔多克隆抗体to FOXP1
  • 经测试应用适用于: IPmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Elephant
  • 免疫原

    Synthetic peptide from a region within amino acids 250-300 of Human FOXP1 (NP_116071.2)

  • 阳性对照
    • HeLa cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab93776 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-5 µg/mg of lysate.

靶标

  • 功能Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.
  • 疾病相关Note=A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.
    Defects in FOXP1 are the cause of mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670]. It is a developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors.
  • 序列相似性Contains 1 C2H2-type zinc finger.
    Contains 1 fork-head DNA-binding domain.
  • 结构域The leucine-zipper is required for dimerization and transcriptional repression.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 12CC4 antibody
    • FLJ23741 antibody
    • Fork head related protein like B antibody
    • Forkhead box P1 antibody
    • Forkhead box protein P1 antibody
    • FOX P1 antibody
    • FOXP 1 antibody
    • foxp1 antibody
    • FOXP1_HUMAN antibody
    • Glutamine rich factor 1 antibody
    • hFKH1B antibody
    • HSPC215 antibody
    • MGC12942 antibody
    • MGC88572 antibody
    • MGC99551 antibody
    • QRF 1 antibody
    • QRF1 antibody
    see all

Anti-FOXP1 antibody 图像

  • 1 mg HeLa whole cell lysate was immunoprecipitated with 3 µg/mg ab93776. 20% of the immunoprecipitate was used for Western blotting and ab93776 was used at 1 µg/ml followed by a chemiluminescence exposure of 10 seconds to reveal the protein bands.

Anti-FOXP1 antibody (ab93776)参考文献

ab93776 has not yet been referenced specifically in any publications.

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