Anti-FOXL2 (phospho S263)抗体(ab74144)

概述

  • 产品名称Anti-FOXL2 (phospho S263)抗体
    参阅全部 FOXL2 一抗
  • 描述
    兔多克隆抗体to FOXL2 (phospho S263)
  • 特异性The antibody detects endogenous levels of FOXL2 when phosphorylated at serine 263.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthesized phosphopeptide derived from human FOXL2 around the phosphorylation site of serine 263 (V-Q-SP-M-A).

  • 阳性对照
    • K562 cells treated with Na3VO4 (0.3nM, 40mins)

性能

应用

Our Abpromise guarantee covers the use of ab74144 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 39 kDa.
ELISA 1/20000.

靶标

  • 功能Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis throught transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
  • 组织特异性In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.
  • 疾病相关Defects in FOXL2 are a cause of blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) [MIM:110100]; also known as blepharophimosis syndrome. It is an autosomal dominant disorder characterized by eyelid dysplasia, small palpebral fissures, drooping eyelids and a skin fold running inward and upward from the lower lid. In type I BPSE (BPES1) eyelid abnormalities are associated with female infertility. Affected females show an ovarian deficit due to primary amenorrhea or to premature ovarian failure (POF). In type II BPSE (BPES2) affected individuals show only the eyelid defects. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II.
    Defects in FOXL2 are a cause of premature ovarian failure type 3 (POF3) [MIM:608996]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
  • 序列相似性Contains 1 fork-head DNA-binding domain.
  • 翻译后修饰Sumoylated by SUMO1; sumoylation is required for transcriptional repression activity.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Blepharophimosis antibody
    • Blepharophimosis epicanthus inversus and ptosis 1 antibody
    • Blepharophimosis epicanthus inversus and ptosis antibody
    • BPES 1 antibody
    • BPES antibody
    • BPES1 antibody
    • Epicanthus inversus and ptosis 1 antibody
    • Forkhead box L2 antibody
    • Forkhead box protein L2 antibody
    • Forkhead transcription factor FOXL2 antibody
    • FOX L2 antibody
    • FOXL 2 antibody
    • FOXL2 antibody
    • FOXL2_HUMAN antibody
    • PFRK antibody
    • PINTO antibody
    • PITUITARY FORKHEAD FACTOR antibody
    • POF 3 antibody
    • POF3 antibody
    see all

Anti-FOXL2 (phospho S263) antibody 图像

  • All lanes : Anti-FOXL2 (phospho S263) antibody (ab74144) at 1/500 dilution

    Lane 1 : K562 cells treated with Na3VO4 (0.3nM, 40mins),
    Lane 2 : K562 cells treated with Na3VO4 (0.3nM, 40mins), with phosphopeptide at 10 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 39 kDa
    Observed band size : 39 kDa

Anti-FOXL2 (phospho S263) antibody (ab74144)参考文献

ab74144 has not yet been referenced specifically in any publications.

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Thank you very much for your interest in ab74144. To our knowledge, ab74144 has not been tested in chicken. We do not have any trial sized or small aliquots. Therefore, I can offer a discount off a future purchase if you buy ab74144 now, test it in chi...

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