概述

  • 产品名称Anti-FOXF1抗体
    参阅全部 FOXF1 一抗
  • 描述
    兔多克隆抗体to FOXF1
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    A region within synthetic peptide: SGASYIKQQP LSPCNPAANP LSGSISTHSL EQPYLHQNSH NGPAELQGIP, corresponding to C terminal amino acids 253-302 of Mouse FOXF1

  • 阳性对照
    • SP2/0 lysate

性能

应用

Our Abpromise guarantee covers the use of ab48828 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/12500.
WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 40 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Probable transcription activator for a number of lung-specific genes.
  • 组织特异性Lung and placenta.
  • 疾病相关Defects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) [MIM:265380]. ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
  • 序列相似性Contains 1 fork-head DNA-binding domain.
  • 结构域Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI450827 antibody
    • FKH L5 antibody
    • FKHL 5 antibody
    • FKHL5 antibody
    • Forkhead (Drosophila) like 5 antibody
    • Forkhead box F1 antibody
    • Forkhead box protein F1 antibody
    • Forkhead drosophila homolog like 5 antibody
    • Forkhead like 5 antibody
    • Forkhead related activator 1 antibody
    • Forkhead related protein FKHL5 antibody
    • Forkhead related transcription factor 1 antibody
    • Forkhead-related activator 1 antibody
    • Forkhead-related protein FKHL5 antibody
    • Forkhead-related transcription factor 1 antibody
    • FOX F1 antibody
    • FOXF 1 antibody
    • foxf1 antibody
    • FOXF1_HUMAN antibody
    • FREAC 1 antibody
    • FREAC-1 antibody
    • FREAC1 antibody
    • HFH 8 antibody
    • MGC105125 antibody
    see all

Anti-FOXF1 antibody 图像

Anti-FOXF1 antibody (ab48828)参考文献

This product has been referenced in:
  • Bonuccelli G  et al. Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature. Am J Pathol 174:1650-62 (2009). WB ; Mouse . Read more (PubMed: 19395651) »

See 1 Publication for this product

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