- 数据表
- 具体的参考文献 (2)
- 实验方案
概述
- 产品名称Anti-FOXF1抗体
参阅全部 FOXF1 一抗 - 描述兔多克隆抗体to FOXF1
- 经测试应用适用于: ICC/IF, IHC-P, WBmore details
- 种属反应性与反应: Human
预测可用于: Mouse, Chicken, Cow, Dog, Xenopus laevis
- 免疫原
Synthetic peptide: SASAALNSGA SYIKQQPLSP CNPAANPLSG SLSTHSLEQP YLHQNSHNAP AELQG, corresponding to amino acids 273-327 of FOXF1
- 阳性对照
- Fetal placental lysate.
性能
- 形式Liquid
- 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- 存储溶液Preservative: None
Constituents: 2% Sucrose, PBS -
Concentration information loading... - 纯度Protein A purified
- 克隆多克隆
- 同种型IgG
- 研究领域
相关产品
- Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab23194 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF | Use at an assay dependent concentration. PubMed: 21341990 | |
| IHC-P | Use at an assay dependent concentration. PubMed: 20722018 | |
| WB | Use a concentration of 2.5 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 40 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T. |
靶标
- 功能Probable transcription activator for a number of lung-specific genes.
- 组织特异性Lung and placenta.
- 疾病相关Defects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) [MIM:265380]. ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
- 序列相似性Contains 1 fork-head DNA-binding domain.
- 结构域Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.
- 细胞定位Nucleus.
- Information by UniProt
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数据库链接
- Entrez Gene: 395624 Chicken
- Entrez Gene: 2294 Human
- Entrez Gene: 15227 Mouse
- Entrez Gene: 399398 Xenopus laevis
- Omim: 601089 Human
- SwissProt: Q12946 Human
- SwissProt: Q61080 Mouse
- SwissProt: Q9W706 Xenopus laevis
see all -
别名
- AI450827 antibody
- FKH L5 antibody
- FKHL 5 antibody
see all
Anti-FOXF1 antibody 图像
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Western blot - FOXF1 antibody (ab23194)Anti-FOXF1 antibody (ab23194) at 1.2 µg/ml + Placenta
Predicted band size : 40 kDa
Observed band size : 38 kDa (why is the actual band size different from the predicted?)
Anti-FOXF1 antibody (ab23194)参考文献
This product has been referenced in:
- Bozyk PD et al. Mesenchymal stromal cells from neonatal tracheal aspirates demonstrate a pattern of lung-specific gene expression. Stem Cells Dev 20:1995-2007 (2011). ICC/IF ; Human . Read more (PubMed: 21341990) »
- Minogue BM et al. Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation. Arthritis Rheum 62:3695-705 (2010). IHC-P ; Human . Read more (PubMed: 20722018) »
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"