概述

  • 产品名称Anti-FOXE3抗体
    参阅全部 FOXE3 一抗
  • 描述
    兔多克隆抗体to FOXE3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within the N terminal amino acids 2-51 (AGRSDMDPPA AFSGFPALPA VAPSGPPPSP LAGAEPGREP EEAAAGRGEA) of Human FOXE3 (NP_036318).

  • 阳性对照
    • SH-SYSY cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab90714 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 疾病相关Defects in FOXE3 are a cause of anterior segment mesenchymal dysgenesis (ASMD) [MIM:107250]; also known as anterior segment ocular dysgenesis (ASOD). ASMD consists of a range of developmental defects in structures at the front of the eye, resulting from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to the cornea, iris, and other components of the anterior chamber during eye development. Mature anterior segment anomalies are associated with an increased risk of glaucoma and corneal opacity. Conditions falling within the phenotypic spectrum include aniridia, posterior embryotoxon, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis.
    Defects in FOXE3 are a cause of congenital primary aphakia (CPA) [MIM:610256]. Aphakia is a rare congenital eye disorder in which the lens is missing. It has been histologically subdivided into primary and secondary forms, in accordance with the severity of defects of the ocular tissues, whose development requires the initial presence of a lens. CPA results from an early developmental arrest, around the 4th-5th week of gestation in humans, that prevents the formation of any lens structure and leads to severe secondary ocular defects, including a complete aplasia of the anterior segment of the eye. In contrast, in secondary aphakic eyes, lens induction has occurred, and the lens vesicle has developed to some degree but finally has progressively resorbed perinatally, leading, therefore, to less-severe ocular defects.
  • 序列相似性Contains 1 fork-head DNA-binding domain.
  • 发展阶段Expressed in the lens during embryonic development. Predominantly expressed in the anterior lens epithelium but with some expression posteriorly. Not expressed in brain in embryos.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Drosphilia Forkhead Homolog Like 12 antibody
    • FKHL 12 antibody
    • FKHL12 antibody
    • Forkhead Box E3 antibody
    • Forkhead box protein E3 antibody
    • Forkhead Related Activator 8 antibody
    • Forkhead related protein FKHL12 antibody
    • Forkhead-related protein FKHL12 antibody
    • Forkhead-related transcription factor 8 antibody
    • Foxe3 antibody
    • FOXE3 forkhead box E3 antibody
    • FOXE3_HUMAN antibody
    • FREAC 8 antibody
    • FREAC-8 antibody
    • FREAC8 antibody
    see all

Anti-FOXE3 antibody 图像

  • Anti-FOXE3 antibody (ab90714) at 1 µg/ml (in 5% skim milk / PBS buffer) + SH-SYSY cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 33 kDa

Anti-FOXE3 antibody (ab90714)参考文献

ab90714 has not yet been referenced specifically in any publications.

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