Anti-FOXD3抗体(ab67758)
Key features and details
- Rabbit polyclonal to FOXD3
- Suitable for: ChIP, WB
- Reacts with: Chicken
- Isotype: IgG
概述
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产品名称
Anti-FOXD3抗体
参阅全部 FOXD3 一抗 -
描述
兔多克隆抗体to FOXD3 -
宿主
Rabbit -
经测试应用
适用于: ChIP, WBmore details -
种属反应性
与反应: Chicken
预测可用于: Mouse, Human -
免疫原
Synthetic peptide derived from N terminal domain of chicken FOXD3 protein
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
存储溶液
Constituent: Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab67758于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ChIP | (1) |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
|
说明 |
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ChIP
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
靶标
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功能
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. -
组织特异性
Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. -
疾病相关
Defects in FOXD3 are associated with susceptibility to autoimmune disease type 1 (AIS1) [MIM:607836]. AIS1 is a disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis). -
序列相似性
Contains 1 fork-head DNA-binding domain. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 395794 Chicken
- Entrez Gene: 27022 Human
- Entrez Gene: 15221 Mouse
- Omim: 611539 Human
- SwissProt: P79772 Chicken
- SwissProt: Q9UJU5 Human
- SwissProt: Q61060 Mouse
- Unigene: 546573 Human
see all -
别名
- AIS1 antibody
- forkhead box D3 antibody
- Forkhead box protein D3 antibody
see all
数据表及文件
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Datasheet download
文献 (6)
ab67758 被引用在 6 文献中.
- Wu Z et al. FOXD3 suppresses epithelial-mesenchymal transition through direct transcriptional promotion of SMAD7 in esophageal squamous cell carcinoma. Mol Carcinog 60:859-873 (2021). PubMed: 34551139
- Li R et al. The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2. Exp Mol Med 52:118-129 (2020). PubMed: 31959866
- Xu W et al. FOXD3 Suppresses Tumor-Initiating Features in Lung Cancer via Transcriptional Repression of WDR5. Stem Cells 37:582-592 (2019). PubMed: 30703266
- Zhao X et al. Risk-Associated Long Noncoding RNA FOXD3-AS1 Inhibits Neuroblastoma Progression by Repressing PARP1-Mediated Activation of CTCF. Mol Ther 26:755-773 (2018). PubMed: 29398485
- Huang J & Chen L IL-1β inhibits osteogenesis of human bone marrow-derived mesenchymal stem cells by activating FoxD3/microRNA-496 to repress wnt signaling. Genesis 55:N/A (2017). PubMed: 28509407
- Guo H et al. The aspirin-induced long non-coding RNA OLA1P2 blocks phosphorylated STAT3 homodimer formation. Genome Biol 17:24 (2016). WB ; Human . PubMed: 26898989