概述

  • 产品名称Anti-FOXC2抗体
    参阅全部 FOXC2 一抗
  • 描述
    兔多克隆抗体to FOXC2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Cow, Dog
  • 免疫原

    A region within synthetic peptide: ASPALPVITK VETLSPESAL QGSPRSAAST PAGSPDGSLP EHHAAAPNGL, corresponding to internal sequence amino acids 218-267 of Human FOXC2

性能

应用

Our Abpromise guarantee covers the use of ab24340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 56 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.
  • 疾病相关Defects in FOXC2 are the cause of lymphedema hereditary type 2 (LMPH2) [MIM:153200]; also known as Meige lymphedema. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment.
    Defects in FOXC2 are a cause of lymphedema-yellow nails (LYYN) [MIM:153300]. LYYN is characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities.
    Defects in FOXC2 are a cause of lymphedema-distichiasis (LYD) [MIM:153400]. LYD is characterized by primary limb lymphedema usually starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices).
  • 序列相似性Contains 1 fork-head DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Drosphilia Forkhead Homolog Like 14 antibody
    • FKHL 14 antibody
    • FKHL14 antibody
    • Forkhead Box C2 antibody
    • Forkhead box protein C2 antibody
    • Forkhead related protein FKHL14 antibody
    • Forkhead-related protein FKHL14 antibody
    • FOX C2 antibody
    • Foxc2 antibody
    • FOXC2_HUMAN antibody
    • LD antibody
    • Mesenchyme fork head protein 1 antibody
    • Mesenchyme Forkhead 1 antibody
    • MFH 1 antibody
    • MFH 1 protein antibody
    • MFH-1 protein antibody
    • MFH1 antibody
    • Transcription factor FKH 14 antibody
    • Transcription factor FKH-14 antibody
    see all

Anti-FOXC2 antibody 图像

Anti-FOXC2 antibody (ab24340)参考文献

This product has been referenced in:
  • Jag UR  et al. Insulin acts through FOXO3a to activate transcription of plasminogen activator inhibitor type 1. Mol Endocrinol 23:1587-602 (2009). WB ; Human . Read more (PubMed: 19608644) »

See 1 Publication for this product

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Read More
Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (T47D Breast Cancer cell line)
Loading amount 100 µg
Specification T47D Breast Cancer cell line
Treatment 10nM siRNA 48 hrs
Blocking step Milk as blocking agent for 3 hour(s) and 0 minute(s) · Concentration: 5%
Username

Dr. F Stanley

Verified customer

提交于 Mar 23 2007

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"