概述

  • 产品名称Anti-FOXA3抗体
    参阅全部 FOXA3 一抗
  • 描述
    兔多克隆抗体to FOXA3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Horse, Cow, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within the C terminal amino acids 301-350 (YNFNHPFSIN NLMSEQTSTP SKLDVGFGGY GAESGEPGVY YQSLYSRSLL) of Mouse FOXA3 (NP_032286).

  • 阳性对照
    • Mouse brain lysate

性能

应用

Our Abpromise guarantee covers the use of ab105523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 37 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.
  • 组织特异性Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined.
  • 序列相似性Contains 1 fork-head DNA-binding domain.
  • 发展阶段Detected in prenatal liver nuclear extracts (12.4-27 weeks estimated gestational age). Not detected in postnatal liver samples.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FKHH3 antibody
    • Fork head-related protein FKH H3 antibody
    • forkhead box A3 antibody
    • Forkhead box protein A3 antibody
    • Foxa3 antibody
    • FOXA3_HUMAN antibody
    • hepatic nuclear factor-3-beta antibody
    • hepatocyte nuclear factor 3 antibody
    • hepatocyte nuclear factor 3 gamma antibody
    • Hepatocyte nuclear factor 3-gamma antibody
    • HNF-3-gamma antibody
    • HNF-3G antibody
    • HNF3B antibody
    • HNF3G antibody
    • TCF-3G antibody
    • TCF3G antibody
    • Transcription factor 3G antibody
    see all

Anti-FOXA3 antibody 图像

  • Anti-FOXA3 antibody (ab105523) at 1 µg/ml + Mouse brain lysate at 10 µg

    Predicted band size : 37 kDa

Anti-FOXA3 antibody (ab105523)参考文献

ab105523 has not yet been referenced specifically in any publications.

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