Anti-Folate Binding Protein抗体(Biotin) (ab34529)

概述

  • 产品名称Anti-Folate Binding Protein抗体(Biotin)
    参阅全部 Folate Binding Protein 一抗
  • 描述
    山羊多克隆抗体to Folate Binding Protein (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: WB, ELISA, Immunomicroscopy, Dot blotmore details
  • 种属反应性
    与反应: Cow
  • 免疫原

    Bovine Folate Binding Protein.

  • 常规说明

    10-20 Biotin molecules per goat IgG molecule.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 1% BSA, 0.42% Potassium phosphate, 0.87% Sodium chloride

    BSA is IgG and Protease free
  • Concentration information loading...
  • 纯度IgG fraction
  • 纯化说明This product is purified by a multi-step process including delipidation, salt fractionation, ion exchange chromatography and extensive dialysis against buffer.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab34529 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
Immunomicroscopy
Dot blot
  • 应用说明Dot: Use at an assay dependent dilution.
    ELISA: 1/4000 - 1/20000.
    This product has been assayed against 1.0µg of Folate Binding Protein in a standard capture ELISA using Peroxidase conjugated streptavidin and ABTS (2,2'-azino-bis-[3-ethylbenthiazoline-6-sulfonic-acid]) as a substrate for 30 minutes at RT.
    IM: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.
    Suitable for other antibody based assays using streptavidin or avidin conjugates.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
    • 组织特异性Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.
    • 疾病相关Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function.
    • 序列相似性Belongs to the folate receptor family.
    • 翻译后修饰Eight disulfide bonds are present.
      The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
    • 细胞定位Cell membrane. Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • adult antibody
      • Adult folate binding protein antibody
      • Adult folate-binding protein antibody
      • FBP antibody
      • Folate Receptor 1 Adult antibody
      • Folate receptor 1 antibody
      • Folate Receptor 1 Precursor antibody
      • Folate receptor adult antibody
      • Folate receptor alpha antibody
      • Folate receptor antibody
      • FOLR antibody
      • FOLR1 antibody
      • FOLR1_HUMAN antibody
      • FR alpha antibody
      • FR-alpha antibody
      • FRalpha antibody
      • KB cells FBP antibody
      • MOV18 antibody
      • Ovarian cancer associated antigen antibody
      • Ovarian tumor associated antigen antibody
      • Ovarian tumor associated antigen MOv18 antibody
      • Ovarian tumor-associated antigen MOv18 antibody
      see all

    Anti-Folate Binding Protein antibody (Biotin) (ab34529)参考文献

    ab34529 has not yet been referenced specifically in any publications.

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