Anti-FOG2抗体(ab121212)

概述

  • 产品名称
  • 描述
    兔多克隆抗体to FOG2
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 745-874 of Human FOG2.

  • 阳性对照
    • Human placenta tissue.

性能

应用

Our Abpromise guarantee covers the use of ab121212 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.
  • 组织特异性
    Widely expressed at low level.
  • 疾病相关
    Defects in ZFPM2 may be a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
    Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3) [MIM:610187]; a form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension.
  • 序列相似性
    Belongs to the FOG (Friend of GATA) family.
    Contains 3 C2H2-type zinc fingers.
    Contains 5 C2HC-type zinc fingers.
  • 结构域
    The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FOG-2 antibody
    • FOG2_HUMAN antibody
    • Friend of GATA 2 antibody
    • Friend of GATA protein 2 antibody
    • Friend of GATA2 antibody
    • hFOG-2 antibody
    • ZFPM2 antibody
    • Zinc finger protein 89B antibody
    • Zinc finger protein M2 antibody
    • Zinc finger protein multitype 2 antibody
    • Zinc finger protein ZFPM2 antibody
    see all

Anti-FOG2 antibody 图像

  • ab121212 at 1/25 dilution staining FOG2 in Paraffin-embedded Human Placenta tissue by Immunohistochemistry.

Anti-FOG2 antibody (ab121212)参考文献

ab121212 has not yet been referenced specifically in any publications.

Product Wall

Application
Immunohistochemistry (Frozen sections)
Blocking step
Serum as blocking agent for 30 minute(s) · Concentration: 10% · Temperature: RT°C
Sample
Rhesus monkey Tissue sections (Brain)
Specification
Brain
Permeabilization
No
Fixative
Paraformaldehyde
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提交于 Sep 02 2014

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