Anti-FOG2抗体(ab121212)

概述

  • 产品名称Anti-FOG2抗体
    参阅全部 FOG2 一抗
  • 描述
    兔多克隆抗体to FOG2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 745-874 of Human FOG2.

  • 阳性对照
    • Human placenta tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab121212 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.
  • 组织特异性Widely expressed at low level.
  • 疾病相关Defects in ZFPM2 may be a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
    Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3) [MIM:610187]; a form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension.
  • 序列相似性Belongs to the FOG (Friend of GATA) family.
    Contains 3 C2H2-type zinc fingers.
    Contains 5 C2HC-type zinc fingers.
  • 结构域The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FOG-2 antibody
    • FOG2_HUMAN antibody
    • Friend of GATA 2 antibody
    • Friend of GATA protein 2 antibody
    • Friend of GATA2 antibody
    • hFOG-2 antibody
    • ZFPM2 antibody
    • Zinc finger protein 89B antibody
    • Zinc finger protein M2 antibody
    • Zinc finger protein multitype 2 antibody
    • Zinc finger protein ZFPM2 antibody
    see all

Anti-FOG2 antibody 图像

  • ab121212 at 1/25 dilution staining FOG2 in Paraffin-embedded Human Placenta tissue by Immunohistochemistry.

Anti-FOG2 antibody (ab121212)参考文献

ab121212 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Frozen sections)
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 10% · Temperature: RT°C
Sample Rhesus monkey Tissue sections (Brain)
Specification Brain
Permeabilization No
Fixative Paraformaldehyde
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提交于 Sep 02 2014

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