概述

  • 产品名称
  • 描述
    兔多克隆抗体to FOG1
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region between residue 175 and 225 of human FOG1 (accession number: NP_722520.2)

  • 阳性对照
    • Human Controls: Breast Carcinoma, Hodgkins Lymphoma, Prostate Carcinoma

性能

应用

Our Abpromise guarantee covers the use of ab84876 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
    • 组织特异性
      Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.
    • 序列相似性
      Belongs to the FOG (Friend of GATA) family.
      Contains 4 C2H2-type zinc fingers.
      Contains 5 C2HC-type zinc fingers.
    • 结构域
      The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.
    • 翻译后修饰
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位
      Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FOG-1 antibody
      • FOG1_HUMAN antibody
      • Friend of GATA 1 antibody
      • Friend of GATA protein 1 antibody
      • Friend of GATA1 antibody
      • ZFPM1 antibody
      • Zinc finger protein antibody
      • Zinc finger protein 89A antibody
      • Zinc finger protein multitype 1 antibody
      • Zinc finger protein ZFPM1 antibody
      see all

    图片

    • Detection of Human FOG1 in formalin-fixed paraffin-embedded section of human Hodgkin's Lymphoma by Immunohistochemistry using ab84876 at a dilution of 1:250. Detection: DAB staining.
    • Detection of Human FOG1 in formalin-fixed paraffin-embedded section of human breast carcinoma by Immunohistochemistry using ab84876 at a dilution of 1:250. Detection: DAB staining.

    文献

    ab84876 has not yet been referenced specifically in any publications.

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