重组Anti-FNTA抗体[EPR4704] (ab109738)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR4704] to FNTA
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
Related conjugates and formulations
概述
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产品名称
Anti-FNTA抗体[EPR4704]
参阅全部 FNTA 一抗 -
描述
兔单克隆抗体[EPR4704] to FNTA -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: ICC/IF or IP -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Jurkat, HeLa, JAR, C6, RAW264.7, PC12, and NIH3T3 cell lysates.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR4704 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab109738于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 44 kDa.
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说明 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 44 kDa. |
靶标
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功能
Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK. -
序列相似性
Belongs to the protein prenyltransferase subunit alpha family.
Contains 5 PFTA repeats. -
翻译后修饰
Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA. - Information by UniProt
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数据库链接
- Entrez Gene: 2339 Human
- Entrez Gene: 14272 Mouse
- Entrez Gene: 25318 Rat
- Omim: 134635 Human
- SwissProt: P49354 Human
- SwissProt: Q61239 Mouse
- SwissProt: Q04631 Rat
- Unigene: 370312 Human
see all -
别名
- CAAX farnesyltransferase alpha subunit antibody
- CAAX farnesyltransferase subunit alpha antibody
- EC 2.5.1.58 antibody
see all
图片
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All lanes : Anti-FNTA antibody [EPR4704] (ab109738) at 1/1000 dilution
Lane 1 : Jurkat cell lysate
Lane 2 : HeLa cell lysate
Lane 3 : JAR cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 44 kDa -
All lanes : Anti-FNTA antibody [EPR4704] (ab109738) at 1/1000 dilution
Lane 1 : C6 cell lysate
Lane 2 : RAW264.7 cell lysate
Lane 3 : PC12 cell lysate
Lane 4 : NIH3T3 cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 44 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab109738 被引用在 4 文献中.
- Pinner AL et al. Protein expression of prenyltransferase subunits in postmortem schizophrenia dorsolateral prefrontal cortex. Transl Psychiatry 10:3 (2020). PubMed: 32066669
- Jiang D et al. Expression of key enzymes in the mevalonate pathway are altered in monocrotaline-induced pulmonary arterial hypertension in rats. Mol Med Rep 16:9593-9600 (2017). PubMed: 29039598
- Miles RR et al. Genome-wide screen for modulation of hepatic apolipoprotein A-I (ApoA-I) secretion. J Biol Chem 288:6386-96 (2013). WB ; Human . PubMed: 23322769
- Cieslik KA et al. Aberrant differentiation of fibroblast progenitors contributes to fibrosis in the aged murine heart: role of elevated circulating insulin levels. FASEB J 27:1761-71 (2013). PubMed: 23303205