概述

  • 产品名称Anti-FMRP抗体
    参阅全部 FMRP 一抗
  • 描述
    兔多克隆抗体to FMRP
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the N terminal region of Human FMRP.

  • 阳性对照
    • Mouse lung tissue lysate

性能

应用

Our Abpromise guarantee covers the use of ab91553 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 71 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
    • 组织特异性Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells.
    • 疾病相关Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:300624]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.
      Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:300623]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:300624]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.
      Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:311360]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
    • 序列相似性Belongs to the FMR1 family.
      Contains 2 KH domains.
    • 翻译后修饰Phosphorylated on several serine residues.
    • 细胞定位Cytoplasm. Nucleus > nucleolus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FMR 1 antibody
      • Fmr1 antibody
      • Fmr1 gene antibody
      • FMR1_HUMAN antibody
      • FMRP antibody
      • Fragile X mental retardation 1 antibody
      • Fragile X mental retardation 1 protein antibody
      • Fragile X mental retardation protein 1 antibody
      • Fragile X mental retardation protein antibody
      • fragile X mental retardation syndrome-related protein 1 antibody
      • fragile X mental retardation, autosomal homolog 1 antibody
      • FRAXA antibody
      • fxr1 antibody
      • MGC87458 antibody
      • POF antibody
      • POF1 antibody
      • Protein FMR-1 antibody
      • Protein FMR1 antibody
      • wu:fb16f11 antibody
      • wu:fd18c10 antibody
      • zgc:66226 antibody
      see all

    Anti-FMRP antibody 图像

    • Anti-FMRP antibody (ab91553) at 1/100 dilution + Mouse lung tissue lysates at 35 µg

      Predicted band size : 71 kDa

    Anti-FMRP antibody (ab91553)参考文献

    ab91553 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab91553.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"