概述

性能

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应用

Our Abpromise guarantee covers the use of ab72421 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100.

靶标

  • 功能Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Protects cells against apoptosis by protecting CDKN1A against degradation.
  • 组织特异性Expressed almost exclusively in the developing and mature central nervous system.
  • 序列相似性Belongs to the formin homology family. Cappuccino subfamily.
    Contains 1 FH1 (formin homology 1) domain.
    Contains 1 FH2 (formin homology 2) domain.
  • 细胞定位Cytoplasm > cytoskeleton. Cytoplasm > perinuclear region. Cytoplasm > cytosol. Cell membrane. Cytoplasmic vesicle membrane. Cytoplasm > cell cortex. Nucleus > nucleolus. Recruited to the membranes via its interaction with SPIRE1. Colocalizes with the actin cytoskeleton. Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FMN 2 antibody
    • Fmn2 antibody
    • FMN2_HUMAN antibody
    • Formin 2 antibody
    • Formin-2 antibody
    see all

Anti-FMN2 antibody 图像

  • Immunohistochemical analysis of FMN2 in paraffin-embedded formalin-fixed human uterus tissue using an isotype control (top) and ab72421 (bottom) at 1:100.

Anti-FMN2 antibody (ab72421)参考文献

ab72421 has not yet been referenced specifically in any publications.

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