概述

  • 产品名称Anti-FLRT1抗体
    参阅全部 FLRT1 一抗
  • 描述
    兔多克隆抗体to FLRT1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 63 and 253 of Human FLRT1 (NP_037412)

  • 阳性对照
    • 293T; A431; H1299; HeLaS3; HepG2; MOLT4 or Raji lysates OVCA (IHC-P)

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab97825 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 74 kDa.
IHC-P 1/100 - 1/250.

靶标

  • 功能Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.
  • 组织特异性Expressed in kidney and brain.
  • 序列相似性Contains 1 fibronectin type-III domain.
    Contains 10 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • 翻译后修饰N-glycosylated.
    Phosphorylated in response to FGFR1 signaling, but is not a direct substrate of FGFR1 or SRC. A mutant where the Tyr phosphorylation sites have been replaced by Phe displays constitutive FGFR1-dependent activation of downstream MAP kinases.
    Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain.
  • 细胞定位Cell membrane. Endoplasmic reticulum membrane. Cytoplasmic vesicle membrane. Cytoplasm, perinuclear region. Cell junction, focal adhesion. Secreted. Cell projection. Cell junction. In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Fibronectin-like domain containing leucine rich transmembrane protein 1 antibody
    • Fibronectin-like domain-containing leucine-rich transmembrane protein 1 antibody
    • FLRT1 antibody
    • FLRT1_HUMAN antibody
    • Leucine rich repeat transmembrane protein FLRT1 antibody
    • Leucine-rich repeat transmembrane protein FLRT1 antibody
    see all

Anti-FLRT1 antibody 图像

  • Immunohistochemical analysis of paraffin embedded OVCA, using ab97825 at 1:100 dilution.
  • All lanes : Anti-FLRT1 antibody (ab97825) at 1/1000 dilution

    Lane 1 : H1299 whole cell lysate
    Lane 2 : HeLaS3 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 74 kDa

Anti-FLRT1 antibody (ab97825)参考文献

ab97825 has not yet been referenced specifically in any publications.

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