Anti-FLRT1抗体(ab97825)
Key features and details
- Rabbit polyclonal to FLRT1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-FLRT1抗体 -
描述
兔多克隆抗体to FLRT1 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 63 and 253 of Human FLRT1 (NP_037412)
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阳性对照
- 293T; A431; H1299; HeLaS3; HepG2; MOLT4 or Raji lysates OVCA (IHC-P)
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab97825于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 74 kDa.
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IHC-P |
1/100 - 1/250.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 74 kDa. |
IHC-P
1/100 - 1/250. |
靶标
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功能
Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3. -
组织特异性
Expressed in kidney and brain. -
序列相似性
Contains 1 fibronectin type-III domain.
Contains 10 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain. -
翻译后修饰
N-glycosylated.
Phosphorylated in response to FGFR1 signaling, but is not a direct substrate of FGFR1 or SRC. A mutant where the Tyr phosphorylation sites have been replaced by Phe displays constitutive FGFR1-dependent activation of downstream MAP kinases.
Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. -
细胞定位
Cell membrane. Endoplasmic reticulum membrane. Cytoplasmic vesicle membrane. Cytoplasm, perinuclear region. Cell junction, focal adhesion. Secreted. Cell projection. Cell junction. In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain. - Information by UniProt
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数据库链接
- Entrez Gene: 23769 Human
- Entrez Gene: 396184 Mouse
- Entrez Gene: 499308 Rat
- Omim: 604806 Human
- SwissProt: Q9NZU1 Human
- SwissProt: Q6RKD8 Mouse
- Unigene: 584876 Human
- Unigene: 386930 Mouse
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别名
- Fibronectin-like domain containing leucine rich transmembrane protein 1 antibody
- Fibronectin-like domain-containing leucine-rich transmembrane protein 1 antibody
- FLRT1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab97825 尚未被引用在任何文献中。