membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)
功能May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
组织特异性In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes.
序列相似性Belongs to the band 7/mec-2 family. Flotillin subfamily.
细胞定位Cell membrane. Membrane > caveola. Endosome. Membrane-associated protein of caveolae.