Anti-Flightless I抗体(ab96314)

概述

  • 产品名称Anti-Flightless I抗体
    参阅全部 Flightless I 一抗
  • 描述
    兔多克隆抗体to Flightless I
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 435-748 of Human Flightless I (NP_002009).

  • 阳性对照
    • WB: 293T, H1299, HeLaS3, MOLT4 and Raji cell lysates ICC/If: Hela cell

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab96314 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 145 kDa.
ICC/IF 1/100 - 1/200.

靶标

  • 功能May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration.
  • 组织特异性Strongest expression in skeletal muscle with high expression also in the heart and lung.
  • 疾病相关Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS) [MIM:182290]. It is a contiguous gene deletion syndrome involving developmental abnormalities and mental retardation. The spectrum of clinical findings includes short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances, and behavioral problems.
  • 序列相似性Contains 5 gelsolin-like repeats.
    Contains 15 LRR (leucine-rich) repeats.
  • 细胞定位Nucleus. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Colocalizes to actin-rich structures in blastocysts and, together with HRAS1, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Fli 1 antibody
    • FLI antibody
    • Fli1 antibody
    • Flightless 1 antibody
    • Flightless I (Drosophila) homolog antibody
    • Flightless I homolog antibody
    • Flightless I homolog (Drosophila) antibody
    • Flightless1 antibody
    • FlightlessI antibody
    • fliI antibody
    • FLII_HUMAN antibody
    • Fliih antibody
    • FLIL antibody
    • MGC39265 antibody
    • Protein flightless 1 homolog antibody
    • Protein flightless-1 homolog antibody
    see all

Anti-Flightless I antibody 图像

  • Anti-Flightless I antibody (ab96314) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size : 145 kDa
  • ab96314 at 1/200 dilution staining Flightless I in paraformaldehyde fixed HeLa cells by Immunofluorescence.
    The lower image shows ab96314 merged with a DNA probe.

Anti-Flightless I antibody (ab96314)参考文献

ab96314 has not yet been referenced specifically in any publications.

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