Anti-Flightless I抗体(ab84778)

概述

  • 产品名称Anti-Flightless I抗体
    参阅全部 Flightless I 一抗
  • 描述
    兔多克隆抗体to Flightless I
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 425 - 475 of Human Flightless I (NP_002009.1)

  • 阳性对照
    • Breast carcinoma, colon carcinoma, ovarian carcinoma, prostate carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab84778 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer may enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration.
    • 组织特异性Strongest expression in skeletal muscle with high expression also in the heart and lung.
    • 疾病相关Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS) [MIM:182290]. It is a contiguous gene deletion syndrome involving developmental abnormalities and mental retardation. The spectrum of clinical findings includes short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances, and behavioral problems.
    • 序列相似性Contains 5 gelsolin-like repeats.
      Contains 15 LRR (leucine-rich) repeats.
    • 细胞定位Nucleus. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Colocalizes to actin-rich structures in blastocysts and, together with HRAS1, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Fli 1 antibody
      • FLI antibody
      • Fli1 antibody
      • Flightless 1 antibody
      • Flightless I (Drosophila) homolog antibody
      • Flightless I homolog antibody
      • Flightless I homolog (Drosophila) antibody
      • Flightless1 antibody
      • FlightlessI antibody
      • fliI antibody
      • FLII_HUMAN antibody
      • Fliih antibody
      • FLIL antibody
      • MGC39265 antibody
      • Protein flightless 1 homolog antibody
      • Protein flightless-1 homolog antibody
      see all

    Anti-Flightless I antibody 图像

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human prostate carcinoma, using 1/100 ab84778 in conjunction with 1/100 Goat anti-Rabbit IgG secondary antibody conjugated to a fluorescent dye (red).
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human breast carcinoma, using 1/250 ab84778 followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human colon carcinoma, using 1/250 ab84778 followed by DAB staining.

    Anti-Flightless I antibody (ab84778)参考文献

    ab84778 has not yet been referenced specifically in any publications.

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