Anti-Flightless I抗体[116.40] (ab28089)

概述

  • 产品名称Anti-Flightless I抗体[116.40]
    参阅全部 Flightless I 一抗
  • 描述
    小鼠单克隆抗体[116.40] to Flightless I
  • 特异性ab28089 recognises Flightless-I Protein.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    The details of the immunogen for this antibody are not available.

性能

应用

Our Abpromise guarantee covers the use of ab28089 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 144 kDa.

靶标

  • 功能May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration.
  • 组织特异性Strongest expression in skeletal muscle with high expression also in the heart and lung.
  • 疾病相关Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS) [MIM:182290]. It is a contiguous gene deletion syndrome involving developmental abnormalities and mental retardation. The spectrum of clinical findings includes short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances, and behavioral problems.
  • 序列相似性Contains 5 gelsolin-like repeats.
    Contains 15 LRR (leucine-rich) repeats.
  • 细胞定位Nucleus. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Colocalizes to actin-rich structures in blastocysts and, together with HRAS1, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Fli 1 antibody
    • FLI antibody
    • Fli1 antibody
    • Flightless 1 antibody
    • Flightless I (Drosophila) homolog antibody
    • Flightless I homolog antibody
    • Flightless I homolog (Drosophila) antibody
    • Flightless1 antibody
    • FlightlessI antibody
    • fliI antibody
    • FLII_HUMAN antibody
    • Fliih antibody
    • FLIL antibody
    • MGC39265 antibody
    • Protein flightless 1 homolog antibody
    • Protein flightless-1 homolog antibody
    see all

Anti-Flightless I antibody [116.40] (ab28089)参考文献

This product has been referenced in:
  • Ambrosino C  et al. Identification of a hormone-regulated dynamic nuclear actin network associated with estrogen receptor alpha in human breast cancer cell nuclei. Mol Cell Proteomics 9:1352-67 (2010). Read more (PubMed: 20308691) »
  • Goodall AH  et al. Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function. Blood 116:4646-4656 (2010). WB ; Human . Read more (PubMed: 20833976) »

See all 2 Publications for this product

Product Wall

Application Western blot
Sample Mouse Cell lysate - whole cell (Mouse monocytes)
Loading amount 20 µg
Specification Mouse monocytes
Treatment LPS for 24hrs
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5%
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提交于 Dec 18 2006

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"