概述

  • 产品名称Anti-FLASH抗体
    参阅全部 FLASH 一抗
  • 描述
    兔多克隆抗体to FLASH
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region between residues 1650 and 1700 of human FLASH (NP_036247.1)

  • 阳性对照
    • Human controls: Breast Carcinoma, Ovarian Carcinoma, Prostate Carcinoma, Small Cell Lung Cancer tissues. Mouse controls: Colon Carcinoma, CT26, Teratoma tissues.
  • 常规说明Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG. Centrifuge microtube to remove product from lid.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab84748 was affinity purified using an epitope specific to FLASH immobilized on solid support.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab84748 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Cytoplasm. Nucleus. Localizes to discrete nuclear foci.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AA387232 antibody
      • C8AP2_HUMAN antibody
      • CASP 8 associated protein 2 antibody
      • CASP8 associated protein 2 antibody
      • CASP8-associated protein 2 antibody
      • CASP8AP2 antibody
      • Caspase 8 associated protein 2 antibody
      • CED 4 antibody
      • CED4 antibody
      • D4Ertd659e antibody
      • FLASH homolog antibody
      • FLASH homolog RIP 25 antibody
      • FLASH homolog RIP25 antibody
      • FLICE associated huge antibody
      • FLICE associated huge protein antibody
      • FLICE-associated huge protein antibody
      • FLJ11208 antibody
      • KIAA1315 antibody
      • mKIAA1315 antibody
      • OTTMUSP00000005125 antibody
      • RIP 25 antibody
      • RIP25 antibody
      • RP23-69G24.1 antibody
      see all

    Anti-FLASH antibody 图像

    • ab84748 at 1/250 dilution staining FLASH in human prostate nodular hypertrophy by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
    • ab84748 at 1/250 dilution staining FLASH in mouse teratoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    Anti-FLASH antibody (ab84748)参考文献

    ab84748 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"