Anti-FLAP抗体[EPR5640] (ab124714)


  • 产品名称Anti-FLAP抗体[EPR5640]
    参阅全部 FLAP 一抗
  • 描述
    兔单克隆抗体[EPR5640] to FLAP
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC/IF,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human FLAP

  • 阳性对照
    • Raji, THP-1, HepG2, and K562 cell lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab124714 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 18 kDa.
  • 应用说明Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • 靶标

    • 功能Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
    • 疾病相关Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
      Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.
    • 序列相似性Belongs to the MAPEG family.
    • 结构域The C-terminal part after residue 140 is mostly unstructured.
    • 细胞定位Nucleus membrane. Endoplasmic reticulum membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 5-lipoxygenase activating protein antibody
      • AL5AP_HUMAN antibody
      • ALOX 5AP antibody
      • ALOX5 AP antibody
      • ALOX5AP antibody
      • Arachidonate 5 lipoxygenase activating protein antibody
      • Arachidonate 5-lipoxygenase-activating protein antibody
      • Five lipoxygenase activating protein antibody
      • FLAP antibody
      • MK 886 binding protein antibody
      • MK-886-binding protein antibody
      see all

    Anti-FLAP antibody [EPR5640] 图像

    • All lanes : Anti-FLAP antibody [EPR5640] (ab124714) at 1/1000 dilution

      Lane 1 : Raji cell lysates
      Lane 2 : THP1 cell lysates
      Lane 3 : HepG2 cell lysates
      Lane 4 : K562 cell lysates

      Lysates/proteins at 10 µg per lane.

      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 18 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-FLAP antibody [EPR5640] (ab124714)参考文献

    ab124714 has not yet been referenced specifically in any publications.

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