概述

  • 产品名称Anti-FLAP抗体
    参阅全部 FLAP 一抗
  • 描述
    山羊多克隆抗体to FLAP
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide:

    C-KTISTTISPLLLIP

    , corresponding to C terminal amino acids 148-161 of Human FLAP

  • 阳性对照
    • Human brain and U937 cell lysates.

性能

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应用

Our Abpromise guarantee covers the use of ab39535 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: Antibody detection limit dilution 1/32,000.
    WB: Use at a concentration of 1 µg/ml. Detects a band of approximately 48 kDa, (predicted molecular weight: 19 kDa). An explanation has not been found for the difference in the two molecular weight values.
    This band was successfully blocked by incubation with the immunising peptide.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
    • 疾病相关Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
      Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.
    • 序列相似性Belongs to the MAPEG family.
    • 结构域The C-terminal part after residue 140 is mostly unstructured.
    • 细胞定位Nucleus membrane. Endoplasmic reticulum membrane.
    • Information by UniProt
    • 数据库链接
      • 别名
        • 5-lipoxygenase activating protein antibody
        • AL5AP_HUMAN antibody
        • ALOX 5AP antibody
        • ALOX5 AP antibody
        • ALOX5AP antibody
        • Arachidonate 5 lipoxygenase activating protein antibody
        • Arachidonate 5-lipoxygenase-activating protein antibody
        • Five lipoxygenase activating protein antibody
        • FLAP antibody
        • MK 886 binding protein antibody
        • MK-886-binding protein antibody
        see all

      Anti-FLAP antibody (ab39535)参考文献

      This product has been referenced in:

      See 1 Publication for this product

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