Anti-FKLF / KLF11抗体[KLF5J027] (ab50780)

概述

  • 产品名称Anti-FKLF / KLF11抗体[KLF5J027]
    参阅全部 FKLF / KLF11 一抗
  • 描述
    小鼠单克隆抗体[KLF5J027] to FKLF / KLF11
  • 经测试应用适用于: Dot blot, WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant Human KLF11

性能

应用

Our Abpromise guarantee covers the use of ab50780 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Dot blot Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Detects a band of approximately 37 kDa (predicted molecular weight: 56 kDa).

靶标

  • 功能Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
  • 组织特异性Ubiquitous. Higher expression in erythroid cells.
  • 疾病相关Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • 序列相似性Belongs to the Sp1 C2H2-type zinc-finger protein family.
    Contains 3 C2H2-type zinc fingers.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 9830142A17 antibody
    • D12Ertd427e antibody
    • FKLF antibody
    • FKLF1 antibody
    • Klf11 antibody
    • KLF11_HUMAN antibody
    • Krueppel like factor 11 antibody
    • Krueppel-like factor 11 antibody
    • MODY7 antibody
    • Tcfcp2l2 antibody
    • TGFB Early Growth Response 2 antibody
    • TGFB-inducible early growth response protein 2 antibody
    • TGFB-inducible early growth response protein 2b antibody
    • TGFB-inducible early growth response protein 3 antibody
    • TIEG 2 antibody
    • TIEG-2 antibody
    • TIEG-3 antibody
    • Tieg2b antibody
    • Transforming Growth Factor Beta Inducible Early Growth Response 2 antibody
    • Transforming growth factor-beta-inducible early growth response protein 2 antibody
    • Transforming growth factor-beta-inducible early growth response protein 3 antibody
    see all

Anti-FKLF / KLF11 antibody [KLF5J027] 图像

Anti-FKLF / KLF11 antibody [KLF5J027] (ab50780)参考文献

ab50780 has not yet been referenced specifically in any publications.

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