概述

  • 产品名称Anti-FKBP52抗体[KN382/EC1]
    参阅全部 FKBP52 一抗
  • 描述
    小鼠单克隆抗体[KN382/EC1] to FKBP52
  • 经测试应用适用于: IHC-Fr, WB, IP, RIA, ICC, Blocking, ELISAmore details
  • 种属反应性
    与反应: Rabbit, Guinea pig, Hamster, Cow, Human, Mink (Mustela), Monkey
  • 免疫原

    Partially purified 9S rabbit uterine progesterone receptor complex enriched preparations.

  • 阳性对照
    • HeLa Heat Shocked Cell Lysate

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应用

Our Abpromise guarantee covers the use of ab69826 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr
WB
IP
RIA
ICC
Blocking
ELISA
  • 应用说明BL: Use at 50-100nm to block the ability of FK506 to promote neurite outgrowth from SH-SY5Y cells.
    EIA: Use at an assay dependent dilution.
    IHC-Fr: Use at an assay dependent dilution.
    ICC: Use at an assay dependent dilution.
    IP: Use at a concentration of 10 µg/ml.
    RIA: Use at an assay dependent dilution.
    WB: Use at a concentration of 2 µg/ml. Detects a band of approximately 59 kDa (predicted molecular weight: 52 kDa). An additional unidentified 50 kDa band may be observed in some cell lysates.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.
    • 组织特异性Widely expressed.
    • 序列相似性Contains 2 PPIase FKBP-type domains.
      Contains 3 TPR repeats.
    • 结构域The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).
      The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.
      The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.
    • 翻译后修饰Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Cytoplasm > cytosol. Nucleus. Cytoplasm > cytoskeleton.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 51 kDa FK506-binding protein antibody
      • 52 kDa FK506 binding protein antibody
      • 52 kDa FK506-binding protein antibody
      • 52 kDa FKBP antibody
      • 59 kDa immunophilin antibody
      • FK506 binding protein 4 antibody
      • FK506-binding protein 4 antibody
      • FKBP 4 antibody
      • FKBP 52 antibody
      • FKBP 59 antibody
      • FKBP-4 antibody
      • FKBP-52 antibody
      • FKBP4 antibody
      • FKBP4_HUMAN antibody
      • FKBP51 antibody
      • FKBP52 protein antibody
      • FKBP59 antibody
      • HBI antibody
      • Hsp 56 antibody
      • HSP binding immunophilin antibody
      • HSP-binding immunophilin antibody
      • Hsp56 antibody
      • Immunophilin FKBP52 antibody
      • N-terminally processed antibody
      • p52 antibody
      • p59 antibody
      • p59 protein antibody
      • Peptidyl prolyl cis trans isomerase antibody
      • Peptidyl-prolyl cis-trans isomerase FKBP4 antibody
      • Peptidylprolyl cis trans isomerase antibody
      • PPIase antibody
      • PPIase FKBP4 antibody
      • Rotamase antibody
      • T cell FK506 binding protein 59kD antibody
      see all

    Anti-FKBP52 antibody [KN382/EC1] (ab69826)参考文献

    This product has been referenced in:
    • Gold BG  et al. Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. J Pharmacol Exp Ther 289:1202-10 (1999). Read more (PubMed: 10336507) »

    See 1 Publication for this product

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