概述

  • 产品名称Anti-FKBP52抗体
    参阅全部 FKBP52 一抗
  • 描述
    山羊多克隆抗体to FKBP52
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    C-DHPTDTEMKEEQKSN

    , corresponding to C terminal amino acids 433-447 of Human FKBP52 (NP_002005.1).

  • 阳性对照
    • Human Brain (Cerebellum) and Human Kidney tissue. Human Placenta lysate

应用

Our Abpromise guarantee covers the use of ab110191 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 52 kDa.
IHC-P Use a concentration of 3.75 µg/ml.

靶标

  • 功能Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.
  • 组织特异性Widely expressed.
  • 序列相似性Contains 2 PPIase FKBP-type domains.
    Contains 3 TPR repeats.
  • 结构域The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).
    The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.
    The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.
  • 翻译后修饰Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm > cytosol. Nucleus. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 51 kDa FK506-binding protein antibody
    • 52 kDa FK506 binding protein antibody
    • 52 kDa FK506-binding protein antibody
    • 52 kDa FKBP antibody
    • 59 kDa immunophilin antibody
    • FK506 binding protein 4 antibody
    • FK506-binding protein 4 antibody
    • FKBP 4 antibody
    • FKBP 52 antibody
    • FKBP 59 antibody
    • FKBP-4 antibody
    • FKBP-52 antibody
    • FKBP4 antibody
    • FKBP4_HUMAN antibody
    • FKBP51 antibody
    • FKBP52 protein antibody
    • FKBP59 antibody
    • HBI antibody
    • Hsp 56 antibody
    • HSP binding immunophilin antibody
    • HSP-binding immunophilin antibody
    • Hsp56 antibody
    • Immunophilin FKBP52 antibody
    • N-terminally processed antibody
    • p52 antibody
    • p59 antibody
    • p59 protein antibody
    • Peptidyl prolyl cis trans isomerase antibody
    • Peptidyl-prolyl cis-trans isomerase FKBP4 antibody
    • Peptidylprolyl cis trans isomerase antibody
    • PPIase antibody
    • PPIase FKBP4 antibody
    • Rotamase antibody
    • T cell FK506 binding protein 59kD antibody
    see all

Anti-FKBP52 antibody 图像

  • ab110191, at 3.75 µg/ml, staining FKBP52 in formalin-fixed, paraffin-embedded Human Brain (Cerebellum) tissue by Immunohistochemistry.
  • ab110191, at 3.75 µg/ml, staining FKBP52 in formalin-fixed, paraffin-embedded Human kidney tissue by Immunohistochemistry.
  • Anti-FKBP52 antibody (ab110191) at 0.01 µg/ml + Human Placenta lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 52 kDa

Anti-FKBP52 antibody (ab110191)参考文献

ab110191 has not yet been referenced specifically in any publications.

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