概述

  • 产品名称Anti-FKBP1B抗体
    参阅全部 FKBP1B 一抗
  • 描述
    小鼠单克隆抗体to FKBP1B
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: MGVEIETISP GDGRTFPKKG QTCVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF EEGAAQLGPL SPLPICPHPC, corresponding to amino acids 1-81 of Human FKBP1B

性能

应用

Our Abpromise guarantee covers the use of ab58075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Associates with the ryanodine receptor (RYR-2) in cardiac muscle sarcoplasmic reticulum and may play a unique physiological role in excitation-contraction coupling in cardiac muscle. There are four molecules of FKBP12.6 per heart muscle RYR. Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • 组织特异性Isoform 1 and isoform 2 are Ubiquitous with highest levels in brain and thymus.
  • 序列相似性Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
    Contains 1 PPIase FKBP-type domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 12.6 kDa FK506-binding protein antibody
    • 12.6 kDa FKBP antibody
    • Calstabin 2 antibody
    • FK506 binding protein 1 like antibody
    • FK506 binding protein 12.6 antibody
    • FK506 binding protein 1B 12.6 kDa antibody
    • FK506 binding protein 1B antibody
    • FK506-binding protein 1B antibody
    • FKB1B_HUMAN antibody
    • FKBP 12.6 antibody
    • FKBP 1B antibody
    • FKBP 1L antibody
    • FKBP 9 antibody
    • FKBP-12.6 antibody
    • FKBP-1B antibody
    • FKBP12.6 antibody
    • Fkbp1b antibody
    • FKBP1L antibody
    • FKBP9 antibody
    • h FKBP 12 antibody
    • h-FKBP-12 antibody
    • Immunophilin FKBP12.6 antibody
    • OTK 4 antibody
    • OTK4 antibody
    • Peptidyl prolyl cis trans isomerase 1B antibody
    • Peptidyl prolyl cis trans isomerase antibody
    • Peptidyl-prolyl cis-trans isomerase FKBP1B antibody
    • PKBP 1L antibody
    • PKBP1L antibody
    • PPIase 1B antibody
    • PPIase antibody
    • PPIase FKBP1B antibody
    • Rotamase 1B antibody
    • Rotamase antibody
    see all

Anti-FKBP1B antibody 图像

  • Western blot against tagged recombinant protein immunogen using ab58075 FKBP1B antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa
  • IHC image of ab58075 staining in human hippocampus formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab58075, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

    For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-FKBP1B antibody (ab58075)参考文献

ab58075 has not yet been referenced specifically in any publications.

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