概述

  • 产品名称Anti-FIP1L1抗体
    参阅全部 FIP1L1 一抗
  • 描述
    兔多克隆抗体to FIP1L1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Horse, Cow, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to a region within amino acids 544 - 594 of Human FIP1L1 (NP_112179.2)

  • 阳性对照
    • Anaplastic thyroid carcinoma, bladder cell carcinoma, breast carcinoma, colon carcinoma, Hodgkin's lymphoma, linitis plastica stomach cancer, lung adenocarcinoma, ovarian carcinoma, pancreatic islet cell tumor, prostate carcinoma, skin basal cell carcinoma, skin squamous cell carcinoma, small cell lung Cancer, stomach adenocarcinoma, skin cancer.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab84670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer may enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性FIP1L1 is an integral subunit of the cleavage and polyadenylation specificity factor (CPSF) complex. CPSF is a multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA and interacts with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 binds to U-rich RNA sequence elements surrounding the poly(A) site and contributes to poly(A) site recognition and stimulates poly(A) addition. FIP1L1 may act to tether poly(A) polymerase to the CPSF complex. A fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA) is a recurrent molecular lesion in eosinophilia-associated myeloproliferative disorders.
    • 细胞定位Nuclear
    • 数据库链接
    • 别名
      • DKFZp586K0717 antibody
      • Factor interacting with PAP antibody
      • FIP1 antibody
      • FIP1 like 1 (S cerevisiae) antibody
      • FIP1 like 1 antibody
      • FLJ33619 antibody
      • hFip 1 antibody
      • hFip1 antibody
      • Pre mRNA 3 end processing factor FIP1 antibody
      • Rearranged in hypereosinophilia antibody
      • RHE antibody
      see all

    Anti-FIP1L1 antibody 图像

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human pancreatic islet cell tumor, using 1/100 ab84670 followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human skin cancer, using 1/100 ab84670 followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Humanbreast carcinoma, using 1/100 ab84670 in conjunction with 1/100 Goat anti-Rabbit IgG conjugated with a fluorescent dye (red).

    Anti-FIP1L1 antibody (ab84670)参考文献

    ab84670 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"