RabMAb

Anti-Fibrinopeptide B抗体[EPR3082] (ab92510)

概述

  • 产品名称Anti-Fibrinopeptide B抗体[EPR3082]
    参阅全部 Fibrinopeptide B 一抗
  • 描述
    兔单克隆抗体[EPR3082] to Fibrinopeptide B
  • 经测试应用适用于: WB, IHC-P, ICCmore details
    不适用于: IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human Fibrinopeptide B.

  • 阳性对照
    • WB: Human prostate and Human plasma lysates IHC-P: Human liver tissue
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab92510 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
ICC
  • 应用说明ICC: 1/100.
    IHC-P: 1/50 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
    WB: 1/5000 - 1/10000. Predicted molecular weight: 56 kDa.

    Is unsuitable for IP.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
    • 疾病相关Defects in FGB are a cause of thrombophilia.
      Defects in FGB are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen.
    • 序列相似性Contains 1 fibrinogen C-terminal domain.
    • 结构域A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
    • 翻译后修饰Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Epididymis secretory sperm binding protein Li 78p antibody
      • FGB antibody
      • FIBB_HUMAN antibody
      • Fibrinogen B beta polypeptide antibody
      • Fibrinogen beta chain antibody
      • Fibrinogen beta polypeptide chain antibody
      • Fibrinopeptide B antibody
      • HEL S 78p antibody
      • Liver regeneration-related protein LRRG036/LRRG043/LRRG189 antibody
      • MGC104327 antibody
      • MGC120405 antibody
      • OTTHUMP00000197066 antibody
      see all

    Anti-Fibrinopeptide B antibody [EPR3082] 图像

    • All lanes : Anti-Fibrinopeptide B antibody [EPR3082] (ab92510) at 1/5000 dilution

      Lane 1 : Human prostate lysate
      Lane 2 : Human plasma lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 56 kDa
    • ab92510, at a 1/50 dilution, staining Fibrinopeptide B in formalin fixed, paraffin embedded Human liver tissue by Immunohistochemistry. Detection: by DAB staining

    Anti-Fibrinopeptide B antibody [EPR3082] (ab92510)参考文献

    ab92510 has not yet been referenced specifically in any publications.

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    Thank you for your phone call. I am still waiting for information regarding the immunogens for ab92481 and ab92510, but I will let you know as soon as I have any additional information.

    DISCOUNT CODE: ***

    Expiration date: August 16t...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"