Anti-Fibrinopeptide B抗体(Biotin) (ab48257)

概述

  • 产品名称Anti-Fibrinopeptide B抗体(Biotin)
    参阅全部 Fibrinopeptide B 一抗
  • 描述
    兔多克隆抗体to Fibrinopeptide B (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: ELISA, IP, RIAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    QGVNDNEEGFFSAR

    conjugated to KLH via carboxyl group, corresponding to amino acids 31-44 of Human Fibrinopeptide B.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 50% Glycerol, PBS, pH 7.5
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab48257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
IP Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

靶标

  • 功能Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
  • 疾病相关Defects in FGB are a cause of thrombophilia.
    Defects in FGB are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen.
  • 序列相似性Contains 1 fibrinogen C-terminal domain.
  • 结构域A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
  • 翻译后修饰Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Epididymis secretory sperm binding protein Li 78p antibody
    • FGB antibody
    • FIBB_HUMAN antibody
    • Fibrinogen B beta polypeptide antibody
    • Fibrinogen beta chain antibody
    • Fibrinogen beta polypeptide chain antibody
    • Fibrinopeptide B antibody
    • HEL S 78p antibody
    • Liver regeneration-related protein LRRG036/LRRG043/LRRG189 antibody
    • MGC104327 antibody
    • MGC120405 antibody
    • OTTHUMP00000197066 antibody
    see all

Anti-Fibrinopeptide B antibody (Biotin) (ab48257)参考文献

ab48257 has not yet been referenced specifically in any publications.

Product Wall

We have added the unconjugated version of ab48257 to the catalog as ab198560 (link below):



http://www.abcam.com/fibrinopeptide-b-antibody-ab198560.html

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"