RabMAb

Anti-Fibrinogen gamma chain抗体[EPR3084] (ab92481)

概述

  • 产品名称Anti-Fibrinogen gamma chain抗体[EPR3084]
    参阅全部 Fibrinogen gamma chain 一抗
  • 描述
    兔单克隆抗体[EPR3084] to Fibrinogen gamma chain
  • 经测试应用适用于: WB, IHC-Pmore details
    不适用于: Flow Cyt or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human Fibrinogen gamma chain (UniProt ID: P02679).

  • 阳性对照
    • WB: Human plasma lysate IHC-P: Human liver tissue
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

Our Abpromise guarantee covers the use of ab92481 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明IHC-P: 1/100 - 1/250. Heat mediated antigen retrieval is recommended before commencing with IHC staining protocol. HRP/AP polymerized antibody is recommended for use as a secondary antibody.
    WB: 1/500 - 1/1000. Predicted molecular weight: 52 kDa.

    Is unsuitable for Flow Cyt or IP.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
    • 疾病相关Defects in FGG are a cause of thrombophilia.
      Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.
    • 序列相似性Contains 1 fibrinogen C-terminal domain.
    • 结构域A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
    • 翻译后修饰Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
      Sulfation of C-terminal tyrosines increases affinity for thrombin.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FGG antibody
      • FIBG_HUMAN antibody
      • Fibrinogen gamma chain antibody
      • Fibrinogen gamma polypeptide antibody
      • fibrinogen gamma-b chain antibody
      see all

    Anti-Fibrinogen gamma chain antibody [EPR3084] 图像

    • Anti-Fibrinogen gamma chain antibody [EPR3084] (ab92481) at 1/500 dilution + Human plasma lysate at 10 µg

      Secondary
      HRP labelled goat anti-rabbit IgG at 1/2000 dilution

      Predicted band size : 52 kDa
    • ab92481, at a 1/100 dilution, staining Fibrinogen gamma chain in paraffin embedded Human liver tissue by Immunohistochemistry.

    Anti-Fibrinogen gamma chain antibody [EPR3084] (ab92481)参考文献

    ab92481 has not yet been referenced specifically in any publications.

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    Thank you for your phone call. I am still waiting for information regarding the immunogens for ab92481 and ab92510, but I will let you know as soon as I have any additional information.

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    Expiration date: August 16t...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"