Anti-Fibrinogen gamma chain抗体(ab96532)

概述

  • 产品名称
    Anti-Fibrinogen gamma chain抗体
    参阅全部 Fibrinogen gamma chain 一抗
  • 描述
    兔多克隆抗体to Fibrinogen gamma chain
  • 经测试应用
    适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 1-415 of Human Fibrinogen gamma chain isoform Gamma A (NP_000500)

  • 阳性对照
    • 293T; A431; H1299; HeLa; or Raji cell lysates. Molt whole cell lysate. HeLa cells.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab96532 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 50 kDa.
ICC/IF 1/100 - 1/200.

靶标

  • 功能
    Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
  • 疾病相关
    Defects in FGG are a cause of thrombophilia.
    Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.
  • 序列相似性
    Contains 1 fibrinogen C-terminal domain.
  • 结构域
    A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
  • 翻译后修饰
    Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
    Sulfation of C-terminal tyrosines increases affinity for thrombin.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FGG antibody
    • FIBG_HUMAN antibody
    • Fibrinogen gamma chain antibody
    • Fibrinogen gamma polypeptide antibody
    • fibrinogen gamma-b chain antibody
    see all

图片

  • Anti-Fibrinogen gamma chain antibody (ab96532) at 1/1000 dilution (10% SDS PAGE) + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 50 kDa
  • Immunofluorescence analysis of paraformaldehyde fixed HeLa using ab96532 at 1/200 dilution: (1) without DNA probe, (2) merged with DNA probe.

文献

ab96532 has not yet been referenced specifically in any publications.

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