Anti-Fibrinogen gamma chain抗体(ab86579)


  • 产品名称Anti-Fibrinogen gamma chain抗体
    参阅全部 Fibrinogen gamma chain 一抗
  • 描述
    兔多克隆抗体to Fibrinogen gamma chain
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (Human) from the C terminus conjugated to KLH.

  • 阳性对照
    • NCI-H460 cell line lysate


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Ammonium Sulphate Precipitation
  • 纯化说明This antibody is prepared by Saturated Ammonium Sulfate precipitation followed by dialysis against PBS.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域


Our Abpromise guarantee covers the use of ab86579 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Predicted molecular weight: 52 kDa.
ELISA 1/1000.


  • 功能Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
  • 疾病相关Defects in FGG are a cause of thrombophilia.
    Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.
  • 序列相似性Contains 1 fibrinogen C-terminal domain.
  • 结构域A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
  • 翻译后修饰Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
    Sulfation of C-terminal tyrosines increases affinity for thrombin.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FGG antibody
    • FIBG_HUMAN antibody
    • Fibrinogen gamma chain antibody
    • Fibrinogen gamma polypeptide antibody
    • fibrinogen gamma-b chain antibody
    see all

Anti-Fibrinogen gamma chain antibody 图像

  • Anti-Fibrinogen gamma chain antibody (ab86579) at 1/50 dilution + NCI-H460 cell line lysate at 35 µg

    Predicted band size : 52 kDa
    Observed band size : 52 kDa
    Additional bands at : 36 kDa,70 kDa. We are unsure as to the identity of these extra bands.

Anti-Fibrinogen gamma chain antibody (ab86579)参考文献

ab86579 has not yet been referenced specifically in any publications.

Product Wall

ab86579 was generated using a synthetic peptide on the C-terminus of the protein. So, for detection methods like Western blot or IHC, the target protein are denatured. Conformational changes would not matter. If you are going to use it to detect native...

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