Anti-Fibrinogen抗体[FgA] (ab20410)

概述

  • 产品名称Anti-Fibrinogen抗体[FgA]
    参阅全部 Fibrinogen 一抗
  • 描述
    小鼠单克隆抗体[FgA] to Fibrinogen
  • 特异性In immunoblots binds A-alpha chain of fibrinogen.
  • 经测试应用适用于: ELISA, RIA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein (Human).

性能

应用

Our Abpromise guarantee covers the use of ab20410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
RIA
WB
  • 应用说明ELISA: Use at an assay dependent dilution. RIA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 95 kDa. Dilution optimised using Chromogenic detection. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
    • 组织特异性Plasma.
    • 疾病相关Defects in FGA are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
      Defects in FGA are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.
    • 序列相似性Contains 1 fibrinogen C-terminal domain.
    • 结构域A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
    • 翻译后修饰The alpha chain is not glycosylated.
      Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.
      About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
      Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
      Phosphorylation sites are present in the extracellular medium.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FGA antibody
      • Fib2 antibody
      • FIBA_HUMAN antibody
      • Fibrinogen A alpha polypeptide antibody
      • Fibrinogen alpha chain antibody
      • Fibrinogen B alpha polypeptide antibody
      • Fibrinogen beta chain antibody
      • Fibrinogen G alpha polypeptide antibody
      • Fibrinogen gamma chain antibody
      • fibrinogen, B beta polypeptide antibody
      • fibrinogen, G gamma polypeptide antibody
      • fibrinogen, gamma polypeptide antibody
      • Fibrinogen--alpha -polypeptide chain antibody
      • Fibrinogen--beta -polypeptide chain antibody
      • Fibrinogen--gamma-polypeptide chain antibody
      see all

    Anti-Fibrinogen antibody [FgA] (ab20410)参考文献

    ab20410 has not yet been referenced specifically in any publications.

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    The Fibrinogen alpha chain sequence of Macaca mulata (http://www.uniprot.org/uniprot/P68110) is 99% similar to human fibrinogen alpha chain (http://www.uniprot.org/uniprot/P02671) so it is more likely that antibodi...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"