Anti-Fibrinogen抗体[40F11] (HRP) (ab10068)


  • 产品名称Anti-Fibrinogen抗体[40F11] (HRP)
    参阅全部 Fibrinogen 一抗
  • 描述
    小鼠单克隆抗体[40F11] to Fibrinogen (HRP)
  • 偶联物HRP
  • 特异性Fibrinogen, Fibrin degradation products.
  • 经测试应用适用于: Sandwich ELISA, ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Fibrin degradation products.

  • 常规说明Concentration varies from lot to lot and can be provided on request.



Our Abpromise guarantee covers the use of ab10068 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Sandwich ELISA Use at an assay dependent dilution. Can be paired for Sandwich ELISA with Mouse monoclonal [1F3] to Fibrinogen (ab10066). Can be used as Detection antibody.
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 104 kDa.


  • 功能Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
  • 组织特异性Plasma.
  • 疾病相关Defects in FGA are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
    Defects in FGA are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.
  • 序列相似性Contains 1 fibrinogen C-terminal domain.
  • 结构域A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
  • 翻译后修饰The alpha chain is not glycosylated.
    Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.
    About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
    Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
    Phosphorylation sites are present in the extracellular medium.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FGA antibody
    • Fib2 antibody
    • FIBA_HUMAN antibody
    • Fibrinogen A alpha polypeptide antibody
    • Fibrinogen alpha chain antibody
    • Fibrinogen B alpha polypeptide antibody
    • Fibrinogen beta chain antibody
    • Fibrinogen G alpha polypeptide antibody
    • Fibrinogen gamma chain antibody
    • fibrinogen, B beta polypeptide antibody
    • fibrinogen, G gamma polypeptide antibody
    • fibrinogen, gamma polypeptide antibody
    • Fibrinogen--alpha -polypeptide chain antibody
    • Fibrinogen--beta -polypeptide chain antibody
    • Fibrinogen--gamma-polypeptide chain antibody
    see all

Anti-Fibrinogen antibody [40F11] (HRP) (ab10068)参考文献

ab10068 has not yet been referenced specifically in any publications.

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Vielen Dank für Ihre Anfrage. In der Tat haben wir einige Antikörper-Paare, die wir für Sandwich-ELISA (sELISA) an humanen Proben garantieren, da die verschiedenen Klone verschiedene Epitope erkennen: Der Klon [1F3] (ab10066) kann mit den Klonen ...

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Thank you for your patience. Regarding ab10068 (Mouse monoclonal [40F11] to Fibrinogen (HRP)), I have received a reply from the originator. As listed in the datasheet: ab10068 can be paired for ELISA with Mouse monoclonal [1F3] to Fibrinogen (ab...

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Thank you for your phone call. Unfortunately I was unable to obtain more information regarding the immunogens. All the information that we have is that Fibrin degradation products were used. If you have any more questions please contact us again.