Anti-Fibrinogen alpha chain抗体[EPR2918] (ab108616)

概述

• 产品名称Anti-Fibrinogen alpha chain抗体[EPR2918]
  参阅全部 Fibrinogen alpha chain 一抗
• 描述
  兔单克隆抗体[EPR2918] to Fibrinogen alpha chain
• 经测试应用适用于: WB, IP, Flow Cytmore details
• 种属反应性
  与反应: Human
  
• 免疫原

  Synthetic peptide corresponding to residues in Human Fibrinogen alpha chain.

• 阳性对照
  • Human plasma and fetal liver lysates
• 常规说明

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• 存储溶液PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 纯度Tissue culture supernatant
• 克隆单克隆
• 克隆编号EPR2918
• 同种型IgG
• 研究领域
  • Immunology
  • Secreted Molecules
  • Other secreted molecules

  • Cardiovascular
  • Atherosclerosis
  • Thrombosis
  • Platelets

  • Signal Transduction
  • Cytoskeleton / ECM
  • Extracellular Matrix
  • ECM Proteins
  • Other ECM Proteins

应用

靶标

• 功能Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
• 组织特异性Plasma.
• 疾病相关Defects in FGA are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
  Defects in FGA are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.
• 序列相似性Contains 1 fibrinogen C-terminal domain.
• 结构域A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
• 翻译后修饰The alpha chain is not glycosylated.
  Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.
  About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
  Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
  Phosphorylation sites are present in the extracelllular medium.
• 细胞定位Secreted.

• Target information above from: UniProt accession P02671 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 2243 Human
  • Omim: 134820 Human
  • SwissProt: P02671 Human
  • Unigene: 351593 Human
• 别名
  • Ac1873 antibody
  • Fba5e antibody
  • FGA antibody

  • Fib antibody
  • Fib2 antibody
  • FIBA_HUMAN antibody
  • Fibrinogen alpha chain antibody
  • Fibrinogen, A alpha polypeptide antibody
  • Fibrinogen--alpha polypeptide chain antibody
  • Fibrinopeptide A antibody

  see all