Anti-Fibrillin 2抗体(ab53804)

概述

  • 产品名称Anti-Fibrillin 2抗体
    参阅全部 Fibrillin 2 一抗
  • 描述
    兔多克隆抗体to Fibrillin 2
  • 经测试应用适用于: ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide: CAGFANRGDVLTGR conjugated to KLH, corresponding to internal sequence amino acids 1055-1067 of Human Fibrillin 2

性能

应用

Our Abpromise guarantee covers the use of ab53804 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.

靶标

  • 功能Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.
  • 疾病相关Defects in FBN2 are the cause of congenital contractural arachnodactyly (CCA) [MIM:121050]; also known as Beals syndrome or distal arthrogryposis type 9 (DA9). CCA is a rare, autosomal dominant connective tissue disorder characterized by contractures, arachnodactyly, scoliosis, and crumpled ears. Phenotypically similar to Marfan syndrome, CCA does not affect the aorta and the eyes.
  • 序列相似性Belongs to the fibrillin family.
    Contains 47 EGF-like domains.
    Contains 9 TB (TGF-beta binding) domains.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CCA antibody
    • congenital contractural arachnodactyly (Marfanoid-like) antibody
    • DA9 antibody
    • FBN2 antibody
    • FBN2_HUMAN antibody
    • fibrillin 2 (congenital contractural arachnodactyly) antibody
    • Fibrillin-2 antibody
    see all

Anti-Fibrillin 2 antibody (ab53804)参考文献

ab53804 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Sample Human Tissue sections (intevertebral disc)
Specification intevertebral disc
Permeabilization No
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 6% · Temperature: RT°C
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提交于 Jan 27 2011

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