概述

  • 产品名称Anti-FH抗体
    参阅全部 FH 一抗
  • 描述
    兔多克隆抗体to FH
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Zebrafish
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 89 and 335 of FH

  • 阳性对照
    • 293T and A431 whole cell lysates OVCAR3 xenograft tissue

性能

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应用

Our Abpromise guarantee covers the use of ab95950 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 55 kDa.
IHC-P 1/100 - 1/500.

靶标

  • 功能Also acts as a tumor suppressor.
  • 通路Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.
  • 疾病相关Defects in FH are the cause of fumarase deficiency (FHD) [MIM:606812]; also known as fumaricaciduria. FHD is characterized by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia.
    Defects in FH are the cause of multiple cutaneous and uterine leiomyomata (MCUL1) [MIM:150800]. MCUL1 is an autosomal dominant condition in which affected individuals develop benign smooth muscle tumors (leiomyomata) of the skin. Affected females also usually develop leiomyomata of the uterus (fibroids).
    Defects in FH are the cause of hereditary leiomyomatosis and renal cell cancer (HLRCC) [MIM:605839].
  • 序列相似性Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  • 细胞定位Cytoplasm and Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FH antibody
    • Fumarase antibody
    • Fumarate hydratase antibody
    • Fumarate hydratase mitochondrial antibody
    • Fumarate hydratase, mitochondrial antibody
    • FUMH_HUMAN antibody
    • HLRCC antibody
    • LRCC antibody
    • MCL antibody
    • MCUL 1 antibody
    • MCUL1 antibody
    • MS709 antibody
    • Multiple hereditary cutaneous leiomyomata antibody
    see all

Anti-FH antibody 图像

  • All lanes : Anti-FH antibody (ab95950) at 1/5000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 55 kDa
  • ab95950 at a 1:500 dilution, staining human FH in OVCAR3 xenograft, using Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.

Anti-FH antibody (ab95950)参考文献

ab95950 has not yet been referenced specifically in any publications.

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