概述

  • 产品名称Anti-FH抗体
    参阅全部 FH 一抗
  • 描述
    山羊多克隆抗体to FH
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Horse, Chicken, Cow, Dog, Pig, Zebrafish, Chinese Hamster
  • 免疫原

    Synthetic peptide:

    C-HPNDHVNKSQSSND

    corresponding to internal sequence amino acids 176-189 of Human FH

  • 阳性对照
    • Human Heart and Human Skeletal Muscle tissue Human Kidney lysate

性能

应用

Our Abpromise guarantee covers the use of ab113963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.01 µg/ml. Predicted molecular weight: 55 kDa.
ELISA 1/64000.
IHC-P Use a concentration of 3.75 µg/ml.

靶标

  • 功能Also acts as a tumor suppressor.
  • 通路Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.
  • 疾病相关Defects in FH are the cause of fumarase deficiency (FHD) [MIM:606812]; also known as fumaricaciduria. FHD is characterized by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia.
    Defects in FH are the cause of multiple cutaneous and uterine leiomyomata (MCUL1) [MIM:150800]. MCUL1 is an autosomal dominant condition in which affected individuals develop benign smooth muscle tumors (leiomyomata) of the skin. Affected females also usually develop leiomyomata of the uterus (fibroids).
    Defects in FH are the cause of hereditary leiomyomatosis and renal cell cancer (HLRCC) [MIM:605839].
  • 序列相似性Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  • 细胞定位Cytoplasm and Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FH antibody
    • Fumarase antibody
    • Fumarate hydratase antibody
    • Fumarate hydratase mitochondrial antibody
    • Fumarate hydratase, mitochondrial antibody
    • FUMH_HUMAN antibody
    • HLRCC antibody
    • LRCC antibody
    • MCL antibody
    • MCUL 1 antibody
    • MCUL1 antibody
    • MS709 antibody
    • Multiple hereditary cutaneous leiomyomata antibody
    see all

Anti-FH antibody 图像

  • Immunohistochemical staining of Human Heart using ab113963 at 3.75µg/ml
  • Immunohistochemical staining of Human Skeletal Muscle using ab113963 at 3.75µg/ml
  • Anti-FH antibody (ab113963) at 0.01 µg/ml + Human Kidney lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 55 kDa

Anti-FH antibody (ab113963)参考文献

This product has been referenced in:
  • Zecchini V  et al. Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer. EMBO J 33:1365-82 (2014). WB, ICC/IF . Read more (PubMed: 24837709) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"