Anti-FGR抗体- Aminoterminal end (ab71680)

概述

  • 产品名称Anti-FGR抗体- Aminoterminal end
    参阅全部 FGR 一抗
  • 描述
    兔多克隆抗体to FGR - Aminoterminal end
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH-conjugated synthetic peptide, from the N-terminal region of Human FGR

  • 阳性对照
    • Ramos cell lysate; Human breast carcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab71680 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Predicted molecular weight: 59 kDa.
IHC-P 1/50 - 1/100.

靶标

  • 功能Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
  • 组织特异性Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.
  • 疾病相关Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • 翻译后修饰Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation.
    Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.
  • 细胞定位Cell membrane. Cell membrane. Cell projection > ruffle membrane. Cytoplasm > cytosol. Cytoplasm > cytoskeleton. Mitochondrion inner membrane. Mitochondrion intermembrane space. Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • c fgr antibody
    • c fgr protooncogene antibody
    • c src 2 proto oncogene antibody
    • c src2 antibody
    • Fgr antibody
    • FGR_HUMAN antibody
    • FLJ43153 antibody
    • Gardner Rasheed feline sarcoma viral (v fgr) antibody
    • Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog antibody
    • Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog antibody
    • MGC75096 antibody
    • p55 c fgr protein antibody
    • P55 FGR antibody
    • P55-FGR antibody
    • p55c fgr antibody
    • p58-Fgr antibody
    • p58c fgr antibody
    • p58c-Fgr antibody
    • Proto oncogene c Fgr antibody
    • Proto oncogene tyrosine protein kinase FGR antibody
    • Proto-oncogene c-Fgr antibody
    • SRC 2 antibody
    • SRC2 antibody
    • Tyrosine protein kinase Fgr antibody
    • Tyrosine-protein kinase Fgr antibody
    see all

Anti-FGR antibody - Aminoterminal end 图像

  • Anti-FGR antibody - Aminoterminal end (ab71680) at 1/100 dilution + Ramos cell lysate at 12.5 µg

    Predicted band size : 59 kDa
    Observed band size : 59 kDa
  • Analysis of FGR expression on formalin-fixed and paraffin-embedded human breast carcinoma tissue using 1/50 ab71680 (peroxidase-conjugated secondary antibody, AEC staining).

Anti-FGR antibody - Aminoterminal end (ab71680)参考文献

ab71680 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab71680.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"