概述

  • 产品名称Anti-FGR抗体
    参阅全部 FGR 一抗
  • 描述
    兔多克隆抗体to FGR
  • 特异性Detects endogenous levels of total FGR protein.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthesized non phosphopeptide derived from human FGR around the phosphorylation site of tyrosine 412 (D-E-YP-N-P).

  • 阳性对照
    • RAW264.7 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab79357 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 59 kDa.
ELISA 1/40000.

靶标

  • 功能Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
  • 组织特异性Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.
  • 疾病相关Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • 翻译后修饰Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation.
    Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.
  • 细胞定位Cell membrane. Cell membrane. Cell projection > ruffle membrane. Cytoplasm > cytosol. Cytoplasm > cytoskeleton. Mitochondrion inner membrane. Mitochondrion intermembrane space. Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • c fgr antibody
    • c fgr protooncogene antibody
    • c src 2 proto oncogene antibody
    • c src2 antibody
    • Fgr antibody
    • FGR_HUMAN antibody
    • FLJ43153 antibody
    • Gardner Rasheed feline sarcoma viral (v fgr) antibody
    • Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog antibody
    • Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog antibody
    • MGC75096 antibody
    • p55 c fgr protein antibody
    • P55 FGR antibody
    • P55-FGR antibody
    • p55c fgr antibody
    • p58-Fgr antibody
    • p58c fgr antibody
    • p58c-Fgr antibody
    • Proto oncogene c Fgr antibody
    • Proto oncogene tyrosine protein kinase FGR antibody
    • Proto-oncogene c-Fgr antibody
    • SRC 2 antibody
    • SRC2 antibody
    • Tyrosine protein kinase Fgr antibody
    • Tyrosine-protein kinase Fgr antibody
    see all

Anti-FGR antibody 图像

  • All lanes : Anti-FGR antibody (ab79357) at 1/500 dilution

    Lane 1 : Extracts from RAW264.7 cells
    Lane 2 : Extracts from RAW264.7 cells with immunizing peptide at 10 µg

    Lysates/proteins at 10 µg per lane.


    Predicted band size : 59 kDa
    Observed band size : 59 kDa

Anti-FGR antibody (ab79357)参考文献

ab79357 has not yet been referenced specifically in any publications.

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