Anti-FGFR4抗体[5B5] (ab44971)
Key features and details
- Mouse monoclonal [5B5] to FGFR4
- Suitable for: ICC/IF, IHC-Fr, Flow Cyt, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG1
概述
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产品名称
Anti-FGFR4抗体[5B5]
参阅全部 FGFR4 一抗 -
描述
小鼠单克隆抗体[5B5] to FGFR4 -
宿主
Mouse -
特异性
ab44971 detects fibroblasts. -
经测试应用
适用于: ICC/IF, IHC-Fr, Flow Cyt, IHC-Pmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Fusion protein corresponding to Human FGFR4.
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阳性对照
- ICC/IF: Human BJ fibroblasts; mouse primary airway cells. IHC-Fr: Human skin fibroblasts. Flow: Human primary adult fibroblasts. IHC-P: Murine abdominal fibroblasts.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: 0.01% PBS -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
5B5 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab44971于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ICC/IF | (2) |
Use at an assay dependent concentration.
|
IHC-Fr | (2) |
Use at an assay dependent concentration.
|
Flow Cyt | (2) |
Use at an assay dependent concentration.
|
IHC-P | (7) |
Use at an assay dependent concentration.
|
说明 |
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ICC/IF
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19. -
组织特异性
Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. -
序列相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
翻译后修饰
Glycosylated.
Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization. -
细胞定位
Membrane. Isoform 2 may be secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 2264 Human
- Entrez Gene: 14186 Mouse
- Omim: 134935 Human
- SwissProt: P22455 Human
- SwissProt: Q03142 Mouse
- Unigene: 165950 Human
- Unigene: 276715 Mouse
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别名
- CD 334 antibody
- CD334 antibody
- CD334 antigen antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (12)
ab44971 被引用在 12 文献中.
- Castro-Viñuelas R et al. Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts. Sci Rep 10:4272 (2020). PubMed: 32144293
- Chen YS et al. Ursodeoxycholic Acid Regulates Hepatic Energy Homeostasis and White Adipose Tissue Macrophages Polarization in Leptin-Deficiency Obese Mice. Cells 8:N/A (2019). PubMed: 30884843
- Hong SP et al. Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy. Nat Commun 10:3840 (2019). PubMed: 31477698
- Kato T et al. Endothelial-mesenchymal transition in human atrial fibrillation. J Cardiol 69:706-711 (2017). PubMed: 27938856
- Sheipouri D et al. Characterisation of the kynurenine pathway in skin-derived fibroblasts and keratinocytes. J Cell Biochem 116:903-22 (2015). PubMed: 25639585