Anti-FGFR1 alpha抗体[M1C4] (ab830)

概述

  • 产品名称Anti-FGFR1 alpha抗体[M1C4]
    参阅全部 FGFR1 alpha 一抗
  • 描述
    小鼠单克隆抗体[M1C4] to FGFR1 alpha
  • 特异性Reacts with alpha isoform of FRFR1.
  • 经测试应用适用于: IP, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant human ectodomain of FGFr1a expressed in E. coli beginning with pro23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences.

  • 表位COOH-terminus of unique NH2-terminal Ig loop of FGFr1. Epitope is within the sequence between glu75 and ser119 of FGFr1a. Epitope is masked in undenatured FGFr1a.

性能

应用

Our Abpromise guarantee covers the use of ab830 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP
WB
  • 应用说明Western blotting: at 1 ug/ml recognizes 10 ng recombinant bacterial, baculo-viral, or native FGFr1.
    Immunoprecipitation: Ig loop I fragment of denatured, intact FGFr1a.
    Immunohistochemistry: untested; predicted to be poor due to masked epitope.
  • 靶标

    • 相关性FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family and contains an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is widely expressed, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM.
    • 细胞定位Cell Membrane
    • 数据库链接
    • 别名
      • BFGFR antibody
      • CD331 antibody
      • CEK antibody
      • FGFBR antibody
      • FGFR1 antibody
      • FLG antibody
      • FLT2 antibody
      • FMS like tyrosine kinase 2 antibody
      • HBGFR antibody
      • KAL2 antibody
      • N SAM antibody
      • OGD antibody
      see all

    Anti-FGFR1 alpha antibody [M1C4] (ab830)参考文献

    ab830 has not yet been referenced specifically in any publications.

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