Anti-FGF8抗体[MM0291-8D24] (ab89550)

概述

  • 产品名称Anti-FGF8抗体[MM0291-8D24]
    参阅全部 FGF8 一抗
  • 描述
    小鼠单克隆抗体[MM0291-8D24] to FGF8
  • 经测试应用适用于: WB, IHC-P, Neutralisingmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length Human FGF8 protein.

性能

应用

Our Abpromise guarantee covers the use of ab89550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 27 kDa.
IHC-P 1/20 - 1/100.
Neutralising Use at an assay dependent concentration.

靶标

  • 功能Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells.
  • 疾病相关Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
    Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
  • 序列相似性Belongs to the heparin-binding growth factors family.
  • 发展阶段In adults expression is restricted to the gonads.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AIGF antibody
    • Androgen induced growth factor antibody
    • Androgen-induced growth factor antibody
    • FGF 8 antibody
    • FGF-8 antibody
    • FGF8 antibody
    • FGF8_HUMAN antibody
    • Fibroblast growth factor 8 (androgen induced) antibody
    • Fibroblast growth factor 8 antibody
    • Fibroblast growth factor 8 precursor antibody
    • HBGF 8 antibody
    • HBGF-8 antibody
    • HBGF8 antibody
    • Heparin-binding growth factor 8 antibody
    • HH6 antibody
    • KAL6 antibody
    see all

Anti-FGF8 antibody [MM0291-8D24] (ab89550)参考文献

ab89550 has not yet been referenced specifically in any publications.

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